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KMID : 0939920110430020108
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대한암학회지
2011 Volume.43 No. 2 p.108 ~ p.116
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An Association Study of Polymorphisms in JAK3 Gene with Lung Cancer in the Korean Population
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Yoo Won-Beak
Jung Hae-Yun
Lim Seung-Joon
Sung Jae-Sook
Park Kyong-Hwa
Ryu Jeong-Seon
Shin Sang-Won
Kim Jun-Suk
Seo Jae-Hong
Kim Yeul-Hong
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Abstract
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Purpose: The genetic alteration of the janus kinases (JAKs), non-receptor tyrosine kinase, is related to the development of human cancers. However, little is known about how the sequence variation of JAK3 contributes to the development of lung cancer. This study investigated whether polymorphisms at the promoter region of the JAK3 gene are associated with the risk of lung cancer in the Korean population.
Materials and Methods: A total of 819 subjects, including 409 lung cancer patients and 410 healthy controls were recruited. The SNaPshot assay and polymerase chain reaction-restriction fragment length polymorphism analysis were used, and logistic regression analyses were performed to characterize the association between polymorphisms of JAK3 and lung cancer risk.
Results: Three polymorphisms (-672 G>A, +64 A>G and +227 G>A) of JAK3 were analyzed for large-scale genotyping (n=819). Statistical analyses revealed that polymorphisms and haplotypes in the JAK3 gene were not significantly associated with lung cancer.
Conclusion: JAK3 gene was not significantly associated with the risk of lung cancer in the Korean population.
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KEYWORD
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Janus kinase 3, Lung cancer, Polymorphism, Haplotypes, Korea
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